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KMID : 1214920180240010076
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Soonchunhyang Medical Science
2018 Volume.24 No. 1 p.76 ~ p.80
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Two Cases of Neonatal Lupus and Literature Review
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Kim Dong-Hyun
Lee Seung-Ju
Kim Tae-Ho
Yoo Gyeong-Hee
Lee Ji-Yeon
Lee Sung-Yul
Chang Sung-Hae
Lee Hyun-Ju
Hong Soon-Auck
Park Joon-Soo
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Abstract
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Neonatal lupus is a rare rheumatic disease. Clinical manifestations include characteristic annular or macular rashes, congenital heart block, cytopenias, and hepatitis. Neonatal lupus is caused by transmission of maternal immunoglobulin G autoantibodies such as anti-SSA/Ro antibody or anti-SSB/La antibody to the fetus through the placenta. We report two cases of neonatal lupus. The first case refers to an 18-day-old male with annular rashes on both cheeks, neutropenia, positive tests for antinuclear antibody, anti-SSA/Ro antibody, and anti-SSB/La antibody. His mother was diagnosed with systemic lupus erythematosus characterized by positive tests for antinuclear antibody, anti-SSA/Ro antibody, and anti-SSB/La antibody. The second case represents a 32-day-old female with annular rash on both hands, soles, and the genital area, neutropenia, hepatitis, positive tests for antinuclear antibody, and anti-SSA/Ro antibody. Skin punch biopsy was conducted. Her mother did not have history of connective tissue diseases. We referred her mother to the division of rheumatology of the department of internal medicine. The mother was suspected with primary Sjogren’s syndrome because of arthralgia and dry eye symptoms with positive tests for antinuclear antibody, anti-SSA/Ro antibody, anti-SSB/La antibody, and rheumatoid factor. It is necessary to suspect neonatal lupus in neonates or infants with characteristic annular rash with or without maternal history of connective tissue disorders.
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KEYWORD
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Neonatal lupus, Autoantibodies, Exanthema
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